UCSF Cell and Genome Engineering Core 

The UCSF Cell and Genome Engineering Core (CGEC) combines cell culture and banking with genome engineering services; the services of the former ES Cell Targeting Core have been expanded to include CRISPR technology and are consolidated within the CGEC. Formerly provided by the Cell Culture Facility, culture and banking services are now provided by CGEC as well.

Email: [email protected]


Gladstone Transgenic Gene Targeting Core

The Gladstone Transgenic Gene targeting core injects either DNA or ES cells to create genetically modified mouse models.

  • Microinjection of DNA
  • Microinjection of ES cells

Contact: Junli Zhang ([email protected])

UCSF Rederivation Core

The core creates new mice by embryo transfer in order to prevent the potential for transmission of pathogens.

Contact: Helen Lu ([email protected])

UCSF Cryopreservation and Resuscitation Core

The core will cryopreserve sperm and embryo and, on request, resuscitate them to re-create mouse lines.

Contact: Khalida Sabeur ([email protected])

Lentiviral RNAi Core

Knowing the functions of the genes involved in a human disease helps us to better create therapies. RNA interference is a powerful way to silence a gene in a cell, allowing research investigators to study the resulting cellular phenotype. We combine the power of RNA interference and the use of lentiviral technologies to create silencing systems for research use. To view our services, click here. If you would like to use these services, simply create a new account at the ViraCore site and complete the requested fields. Creating an account gives you access to Core services including virus production, a lentivirus vector database, important biosafety information, and e-office hours for trouble-shooting your RNAi experiments.